![]() ![]() ![]() Macrophages are heterogeneous and derive from two main lineages. Macrophages are myeloid-derived cells that populate all tissues, where they contribute to tissue remodelling and protection against pathogens and injury 1. Our study reveals that RXR signalling controls the maintenance of the serous macrophage pool and that targeting peritoneal LPMs may improve ovarian cancer outcomes. We also find that peritoneal LPMs infiltrate early ovarian tumours and that RXR deletion diminishes LPM accumulation in tumours and strongly reduces ovarian tumour progression in mice. RXR deficiency impairs neonatal expansion of the LPM pool and reduces the survival of adult LPMs through excess lipid accumulation. Here, we show that RXRs control mouse serous-macrophage identity by regulating chromatin accessibility and the transcriptional regulation of canonical macrophage genes. We recently found that serous-cavity TRMs (LPMs) are highly enriched in RXR transcripts and RXR-response elements. However, TRM identity and the mechanisms that maintain TRMs in tissues remain poorly understood. TRMs express a molecular program that is mostly shaped by tissue cues. Tissue-resident macrophages (TRMs) populate all tissues and play key roles in homeostasis, immunity and repair. ![]()
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